SR 9243

Key Product Details

Product Description

SR 9243 is a selective LXR inverse agonist. Exhibits no significant activity at other nuclear receptors at maximally effective concentration. Inhibits the Warburg effect and lipogenesis by down-regulation of LXR-mediated gene expression. Selectively reduces cell viability and induces apoptosis in cancer cell lines in vitro. Suppresses hepatic steatosis and inhibits growth of tumor xenografts in mice.

Product Specifications for SR 9243

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SR 9243

The following data is based on the product molecular weight 626.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	7.98 mL	39.90 mL	79.79 mL
1 mM	1.60 mL	7.98 mL	15.96 mL
2 mM	0.80 mL	3.99 mL	7.98 mL
10 mM	0.16 mL	0.80 mL	1.60 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Flaveny Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis. Cancer Cell. 2015 PMID: 26120082

Product Documents for SR 9243