Src I1

Key Product Details

Product Description

Src I1 is a potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC₅₀ values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC₅₀ values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 (Cat. No. 1397) and PP 2 (Cat. No. 1407) to inhibit Src family kinases.

Product Specifications for Src I1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Src I1

The following data is based on the product molecular weight 373.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.39 mL	26.78 mL
5 mM	0.54 mL	2.68 mL	5.36 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Tian Structural determinants for potent, selective dual site inhibition of human pp60^c-src by 4-anilinoquinazolines. Biochem. 2001 PMID: 11401553
• Bain The selectivity of protein kinase inhibitors: a further update. Biochem.J. 2007 PMID: 17850214

Product Documents for Src I1