STAD 2
Tocris Bioscience | Catalog # 6566
AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable
Discontinued Product
6566 has been discontinued.
View all AKAP Inhibitors products.
Key Product Details
Description
AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable
Product Description
STAD 2 is an AKAP disruptor. Selectively binds PKA-RII subunit with high affinity (Kd = 6.2 nM) and blocks its interaction with AKAP. Cell permeable. Selectively permeable to malaria-infected red blood cells and displays antimalarial activity through a PKA-independent mechanism.
Product Specifications for STAD 2
Molecular Weight
2096.68
Formula
C102H182N24O22
Storage
Store at -20°C
CAS Number
1542100-77-5
SMILES
CC(C[C@@H](C(N[C@H](C(N)=O)CCCCN)=O)NC([C@@H](NC([C@@]1(CCC/C=C/CCC[C@](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(COCCOCCOCCN)=O)CCCCN)=O)CCCCN)=O)CC(C)C)=O)C)=O)CCCCN)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)=O)CO)=O)(C(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)CCCCN)=O)CC(C)C)=O)C)=O)C)C)=O)C)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Solubility
| Solubility | Soluble to 1mg/ml in 50% acetonitrile / water |
Calculators
Background References
References are publications that support the biological activity of the product.
- Flaherty The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism. PLoS One 2015 PMID: 26010880
- Wang Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem.Biol. 2014 PMID: 24422448
- Bendzunas Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg.Med.Chem. 2018 PMID: 29449124
Product Documents for STAD 2
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for STAD 2
For research use only
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