Stattic

Tocris Bioscience | Catalog # 2798

Selective STAT3 inhibitor
Tocris Bioscience

Key Product Details

Description

Selective STAT3 inhibitor
View all STAT Inhibitors »

Product Description

Stattic is a small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Product Specifications for Stattic

Molecular Weight

211.19

Formula

C8H5NO4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6-Nitrobenzo[b]thiophene 1,1-dioxide

CAS Number

19983-44-9

PubChem ID

2779853

InChI Key

ZRRGOUHITGRLBA-UHFFFAOYSA-N

SMILES

O=S2(C1=CC([N+]([O-])=O)=CC=C1C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.56 50

Preparing Stock Solutions for Stattic

The following data is based on the product molecular weight 211.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 9.47 mL 47.35 mL 94.70 mL
2.5 mM 1.89 mL 9.47 mL 18.94 mL
5 mM 0.95 mL 4.74 mL 9.47 mL
25 mM 0.19 mL 0.95 mL 1.89 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 94 publications citing the usage of this product.

Product Documents for Stattic

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Stattic

For research use only

Customer Reviews for Stattic (3)

4.3 out of 5
3 Customer Ratings
5 Stars
67%
4 Stars
0%
3 Stars
33%
2 Stars
0%
1 Stars
0%

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  • Excellent inhibitor
    Name: Sagar Kale
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 08/25/2023
    Used invivo in mice to inhibit STAT3
  • Mitochondrial bioenergetics measurements by reagent screen
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: mouse brain endothelioma cell line
    Verified Customer | Posted 03/15/2020
    10 μM
    Stattic 2798
  • Static inhibition of STAT3 pathway
    Name: Mark Stauffer
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: U87
    Verified Customer | Posted 01/04/2018
    Used to potentially inhibit signal transduction of the stat3 pathway in U87 cells, and was compared with other potential inhibitors in their effectivness of signal transduction when treating cells with pathway activators. It was assessed using RT-PCR for markers of pathway activation to see what inhibitor was most effective.

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