STX 64

Key Product Details

Product Description

STX 64 is a potent steroid sulfatase inhibitor (IC₅₀ = 8 nM). Estrone sulfate-stimulated uterine growth and mammary tumor growth are inhibited by STX 64 in animal models. STX 64 shows inhibition of steroid sulfatase activity in peripheral blood lymphocytes, liver and tumor tissues and is active in vivo. STX 64 is also a potent inhibitor of carbonic anhydrase II (IC₅₀ = 25 nM).

Product Specifications for STX 64

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for STX 64

The following data is based on the product molecular weight 309.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.23 mL	16.16 mL	32.33 mL
5 mM	0.65 mL	3.23 mL	6.47 mL
10 mM	0.32 mL	1.62 mL	3.23 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Purohit In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Res. 2000 PMID: 10910045
• Raobaikady Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. J.Steroid Biochem.Mol.Biol. 2003 PMID: 12711022
• Ho Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates. Biochem.Biophys.Res.Commun. 2003 PMID: 12767917

Product Documents for STX 64