SU 6656

Key Product Details

Product Description

SU 6656 is a potent ATP-competitive Src family kinase inhibitor (IC₅₀ values are 0.02, 0.13, 0.17, 0.28 and 6.88 nM for Yes, Lyn, Fyn, Src and Lck, respectively). Exhibits > 6.5 fold selectivity for Src family over other kinases. Also AMPK inhibitor (IC₅₀ = 0.22 μM for the α2 kinase domain). Cell permeable.

Product Specifications for SU 6656

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SU 6656

The following data is based on the product molecular weight 371.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

• Blake SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol.Cell Biol. 2000 PMID: 11074000
• Ross Mechanisms of paradoxical activation of AMPK by the kinase inhibitors SU6656 and sora. Cell.Chem.Biol. 2017 PMID: 28625738

Product Documents for SU 6656