Talniflumate

Tocris Bioscience | Catalog # 2510

CaCC blocker and Cl-/HCO3- exchange inhibitor
Tocris Bioscience
Discontinued Product
2510 has been discontinued. View all Calcium-activated Chloride Channel Blockers products.

Key Product Details

Description

CaCC blocker and Cl-/HCO3- exchange inhibitor
View all Calcium-activated Chloride Channel Blockers »

Product Description

Talniflumate is a calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

Product Specifications for Talniflumate

Molecular Weight

414.34

Formula

C21H13F3N2O4

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester

CAS Number

66898-62-2

PubChem ID

48229

InChI Key

ANMLJLFWUCQGKZ-UHFFFAOYSA-N

SMILES

FC(F)(F)C1=CC(NC2=NC=CC=C2C(=O)OC2OC(=O)C3=CC=CC=C23)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.36 25

Preparing Stock Solutions for Talniflumate

The following data is based on the product molecular weight 414.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.65 mL 48.27 mL 96.54 mL
1.25 mM 1.93 mL 9.65 mL 19.31 mL
2.5 mM 0.97 mL 4.83 mL 9.65 mL
12.5 mM 0.19 mL 0.97 mL 1.93 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for Talniflumate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Talniflumate

For research use only

Customer Reviews for Talniflumate (1)

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  • Activity evaluation of Talniflumate carried out.
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 08/26/2019
    Cells were were incubated with different concentrations of Talniflumate (50, 100, 150 and 200 mkM), gefitinib and the combination of talniflumate and gefitinib for 24h.
    Activity evaluation of Talniflumate carried out. Human pancreatic cancer cell line MIA PaCa and BxPC-3 were used.

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