Tanshinone IIA
Chemical Name: 6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione
Purity: ≥98%
Biological Activity
Tanshinone IIA is a major tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Displays antioxidant and anti-inflammatory properties.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Anticancer effects of tanshinone I in human non-small cell lung cancer.
Lee et al.
Mol.Cancer Ther., 2008;7:3527 -
Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells.
Wang et al.
J.Neurooncol., 2007;82:11 -
Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway.
Jin et al.
J.Cell Biochem., 2008;104:15 -
Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway.
Dong et al.
Mol.Biol.Rep., 2012;39:6495 -
The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D
AL Rodrigues, HY Liu, YW Chen, M Porotto, A Moscona, HW Snoeck
Nature Protocols, 2021;0(0):.
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for Tanshinone IIA
The citations listed below are publications that use Tocris products. Selected citations for Tanshinone IIA include:
1 Citation: Showing 1 - 1
-
RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1.
Authors: Pedersen Et al.
J Cell Sci 2012;125:5379
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Tanshinone IIA
There are currently no reviews for this product. Be the first to review Tanshinone IIA and earn rewards!
Have you used Tanshinone IIA?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
