TC-E 5005

Tocris Bioscience | Catalog # 4572

Potent and selective PDE10A inhibitor
Tocris Bioscience
Discontinued Product
4572 has been discontinued. View all Phosphodiesterase Inhibitors products.

Key Product Details

Description

Potent and selective PDE10A inhibitor
View all Phosphodiesterase Inhibitors »

Product Description

TC-E 5005 is a potent and selective PDE10A inhibitor (IC50 values are 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively and >5000 nM at PDE1B, 4A, 6, 8A and 9A). Reverses MK 801-induced hyperactivity in vivo.

Product Specifications for TC-E 5005

Molecular Weight

270.33

Formula

C15H18N4O

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

2-Methoxy-6,7-dimethyl-9-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine

CAS Number

959705-64-7

PubChem ID

24802717

InChI Key

YNADXFWEXJTQSZ-UHFFFAOYSA-N

SMILES

CC2=NC1=CC=C(OC)N=C1N3C2=C(C)N=C3CCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 27.03 100
Ethanol 27.03 100

Preparing Stock Solutions for TC-E 5005

The following data is based on the product molecular weight 270.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.70 mL 18.50 mL 36.99 mL
5 mM 0.74 mL 3.70 mL 7.40 mL
10 mM 0.37 mL 1.85 mL 3.70 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TC-E 5005

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TC-E 5005

For research use only

Customer Reviews for TC-E 5005 (1)

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  • PDE inhibition assay in tissue culture
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Hela x fibroblast hybrid
    Verified Customer | Posted 01/04/2018
    Gentle warming of solution while resuspending in 45C water bath was very helpful in the process.
    Dosed product into cell culture media to final concentration of 10uM and at various time points up to 72h and isolated RNA from cells for downstream qPCR analysis to review effect of PDE inhibition on cell line phenotype.

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