TC Mps1 12
Chemical Name: 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
Purity: ≥99%
Biological Activity
TC Mps1 12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4 nM). Selective for Mps1 over a panel of 95 kinases including JNK. Inhibits A549 lung carcinoma cell proliferation and attenuates A549 cell xenograft growth in mice. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.
Kusakabe et al.
ACS Med.Chem.Lett., 2012;3:560
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Citation for TC Mps1 12
The citations listed below are publications that use Tocris products. Selected citations for TC Mps1 12 include:
1 Citation: Showing 1 - 1
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TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.
Authors: Choi Et al.
Br.J.Pharmacol. 2017;174:1810
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