TCB-2

Tocris Bioscience | Catalog # 2592

High affinity and potent 5-HT2A agonist
Tocris Bioscience

Key Product Details

Description

High affinity and potent 5-HT2A agonist
View all 5-HT2A Receptor Agonists »

Product Description

TCB-2 is a high affinity 5-HT2A receptor agonist (Ki values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors (EC50 = 36 nM). Induces head twitches and hypothermia in mice following i.p. administration.

Product Specifications for TCB-2

Molecular Weight

353.05

Formula

C11H14BrNO2.HBr

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

(4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide

CAS Number

912342-28-0

PubChem ID

71433791

InChI Key

TYMMXVZAUGQKRF-UHFFFAOYSA-N

SMILES

Br.COC1=C2C(CN)CC2=C(OC)C(Br)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.83 25
DMSO 35.3 100

Preparing Stock Solutions for TCB-2

The following data is based on the product molecular weight 353.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.16 mL 28.32 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 81 publications citing the usage of this product.

Product Documents for TCB-2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TCB-2

For research use only

Customer Reviews for TCB-2 (1)

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  • 5-HT has a potential for relaxant
    Name: Anonymous
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 02/18/2020
    TCB-2 (5-HT2A)(0.0001 mol/L)
    TCB-2 2592

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