TCID

Key Product Details

Product Description

TCID is a selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC₅₀ = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.

Product Specifications for TCID

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TCID

The following data is based on the product molecular weight 283.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.04 mL	35.22 mL	70.44 mL
2.5 mM	1.41 mL	7.04 mL	14.09 mL
5 mM	0.70 mL	3.52 mL	7.04 mL
25 mM	0.14 mL	0.70 mL	1.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• de Juan-Sanz Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS ONE 2013 PMID: 23484054
• Liu Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 2003 PMID: 14522054

Product Documents for TCID