TCN 213

Key Product Details

Product Description

TCN 213 is a NMDA receptor antagonist, selective for GluN1/GluN2A (formally NR1/NR2A) (pIC₅₀ = 5.4) over GluN1/GluN2B (formally NR1/NR2B) containing receptors.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for TCN 213

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TCN 213

The following data is based on the product molecular weight 376.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.54 mL	17.71 mL	35.41 mL
3.75 mM	0.71 mL	3.54 mL	7.08 mL
7.5 mM	0.35 mL	1.77 mL	3.54 mL
37.5 mM	0.07 mL	0.35 mL	0.71 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• McKay Direct pharmacological monitoring of the developmental switch in NMDAR subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. Br.J.Pharmacol. 2012 PMID: 22022974
• Bettini Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J.Pharmacol.Exp.Ther. 2010 PMID: 20810618

Product Documents for TCN 213