TCS 1205

Key Product Details

Product Description

GABA_A α2 agonist and GABA_A α1 partial agonist in vitro (K_i values are 14 and 121 nM respectively). Exhibits non-sedative anxiolytic activity in vivo.

Product Specifications for TCS 1205

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TCS 1205

The following data is based on the product molecular weight 337.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.82 mL	29.64 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Taliani Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABA_A) κ₂ benzodiazepine receptor. J.Med.Chem. 2009 PMID: 19469479
• Primofiore Novel N-(arylalkyl)indol-3-ylglyoxylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. J.Med.Chem. 2001 PMID: 11428922

Product Documents for TCS 1205