TCS 359

Key Product Details

Product Description

TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC₅₀ = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC₅₀ = 340 nM).

Product Specifications for TCS 359

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TCS 359

The following data is based on the product molecular weight 360.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	9.25 mL	46.24 mL	92.48 mL
1.5 mM	1.85 mL	9.25 mL	18.50 mL
3 mM	0.92 mL	4.62 mL	9.25 mL
15 mM	0.18 mL	0.92 mL	1.85 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Patch Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 2006 PMID: 16580199

Product Documents for TCS 359