TDI 11861

Key Product Details

Product Description

TDI 11861 is a potent and selective soluble adenylyl cyclase (sAC) inhibitor (IC₅₀ values are 3.3 nM and 5.5 nM in biochemical and cellular assays, respectively; K_d = 1.4 nM). Inhibits cellular sAC-specific cAMP accumulation (IC₅₀ = 7 nM) and blocks sperm capacitation in vitro. Cell permeable, not cytotoxic and suitable for both in vivo and in vitro use.

Licensing Information

Sold under license from Cornell University

Product Specifications for TDI 11861

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TDI 11861

The following data is based on the product molecular weight 494.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.10 mL	20.20 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Balbach On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat.Commun. 2023 PMID: 36788210
• Miller Design, synthesis, and pharmacological evaluation of second-generation soluble adenylyl cyclase (sAC, ADCY10) inhibitors with slow dissociation rates. J.Med.Chem. 2022 PMID: 36346696

Product Documents for TDI 11861