Telaprevir

Tocris Bioscience | Catalog # 6658

Hepatitis C virus (HCV) protease NS3/4A inhibitor
Tocris Bioscience
Discontinued Product
6658 has been discontinued. View all Additional Synthetic Protease Inhibitors products.

Key Product Details

Description

Hepatitis C virus (HCV) protease NS3/4A inhibitor

Alternative Names

VX-950,LY-570310
View all Additional Synthetic Protease Inhibitors »

Product Description

Telaprevir is a hepatitis C virus (HCV) protease NS3/4A inhibitor. Orally bioavailable. Inhibits HCV RNA replication in vitro (IC50 = 0.35 μM). Also used in Stabilizable Polypeptide Linkages (StaPLs) chemogenetic platform, for pharmacological regulation of protein expression/function. StaPL sequences can be engineered into target proteins rendering them functional only in the presence of Telaprevir.

Plasmid vectors for the transfection of cells with StaPLs are available from Addgene.

Product Specifications for Telaprevir

Molecular Weight

679.85

Formula

C36H53N7O6

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide

CAS Number

402957-28-2

PubChem ID

3010818

InChI Key

BBAWEDCPNXPBQM-GDEBMMAJSA-N

SMILES

[H][C@@]12CCC[C@@]1([C@@H](C(N[C@H](C(C(NC3CC3)=O)=O)CCC)=O)N(C([C@H](C(C)(C)C)NC([C@H](C4CCCCC4)NC(C5=NC=CN=C5)=O)=O)=O)C2)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 67.98 100

Preparing Stock Solutions for Telaprevir

The following data is based on the product molecular weight 679.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.47 mL 7.35 mL 14.71 mL
5 mM 0.29 mL 1.47 mL 2.94 mL
10 mM 0.15 mL 0.74 mL 1.47 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Telaprevir

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Telaprevir

For research use only

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