TGN 020

Key Product Details

Product Description

TGN 020 is an aquaporin 4 (AQP4) channel blocker (IC₅₀ = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

Product Specifications for TGN 020

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TGN 020

The following data is based on the product molecular weight 206.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	24.25 mL	121.23 mL	242.46 mL
1 mM	4.85 mL	24.25 mL	48.49 mL
2 mM	2.42 mL	12.12 mL	24.25 mL
10 mM	0.48 mL	2.42 mL	4.85 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

• Igarashi Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 2013 PMID: 23462267
• Igarashi and Huber Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 2011 PMID: 20924629
• Huber Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 2009 PMID: 18182301

Product Documents for TGN 020