TH 1217

Tocris Bioscience | Catalog # 6522

Potent dCTP pyrophosphatase 1 inhibitor
Tocris Bioscience
Discontinued Product
6522 has been discontinued. View all Hydrolase Inhibitors products.

Key Product Details

Description

Potent dCTP pyrophosphatase 1 inhibitor
View all Hydrolase Inhibitors »

Product Description

TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor (IC50 = 47 nM).

TH 1217 is not stable in aqueous solution. It is recommended that fresh samples are prepared and used immediately.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Product Specifications for TH 1217

Molecular Weight

491.09

Formula

C20H17BCl2N4O6

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

CAS Number

1862212-48-3

PubChem ID

137919863

InChI Key

HWFRCQHNILGMLL-UHFFFAOYSA-N

SMILES

CC1=NC2=C([N+]([O-])=O)C(Cl)=C(C=C2N1CC3=CC=C([B-]45OC(C[N+](CC(O5)=O)4C)=O)C=C3)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.11 100

Preparing Stock Solutions for TH 1217

The following data is based on the product molecular weight 491.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.18 mL 20.36 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
10 mM 0.20 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TH 1217

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TH 1217

For research use only

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