TH 1760

Key Product Details

Product Description

TH 1760 is a potent and selective NUDT15 (nudix hydrolase 15) inhibitor (IC₅₀ = 29 nM). Displays selectivity for NUDT15 when assayed at 100 μM against other Nudix enzymes (MTH1, NUDT2, 5, 9, 12, 14, 18, 22) and pyrophosphatases or at 10 μM when assayed with a Eurofins Cerep Safety Screen44 panel. In vitro, TH 1760 treatment sensitizes cancer cell lines (NB4 and HL-60) to thiopurine.

Product Specifications for TH 1760

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TH 1760

The following data is based on the product molecular weight 426.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.45 mL	117.25 mL	234.49 mL
0.5 mM	4.69 mL	23.45 mL	46.90 mL
1 mM	2.34 mL	11.72 mL	23.45 mL
5 mM	0.47 mL	2.34 mL	4.69 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zhang Development of a chemical probe against NUDT15. Nat.Chem.Biol. 2020 PMID: 32690945

Product Documents for TH 1760