TH 588

Key Product Details

Product Description

TH 588 is a potent MTH1 inhibitor (IC₅₀ = 5 nM). Induces oxidative DNA damage and reduces survival in cancer cells. Inhibits growth of breast and colorectal cancer xenografts in mice.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Product Specifications for TH 588

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TH 588

The following data is based on the product molecular weight 295.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.39 mL	16.94 mL	33.88 mL
5 mM	0.68 mL	3.39 mL	6.78 mL
10 mM	0.34 mL	1.69 mL	3.39 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Gad MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 2014 PMID:  24695224

Product Documents for TH 588