Thalidomide-Cyanine 5

Tocris Bioscience | Catalog # 7288

High affinity cereblon fluorescent probe
Tocris Bioscience

Key Product Details

Description

High affinity cereblon fluorescent probe

Wavelength

Excitation = 650 nm, Emission = 665 nm
View all Fluorescent Receptor Probes »

Product Description

Thalidomide-Cyanine 5 is a fluorescent probe for cereblon E3 ligases. Binds with high affinity to DDB1-CRBN. Suitable for use in TR-FRET.

Optical Data

Thalidomide-Cyanine 5 Dye Spectra
Emission Color Red
λabs 650 nm
λem 665 nm
Closest Laser line 647 nm
Application TR-FRET

Spectra Viewer

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Product Specifications for Thalidomide-Cyanine 5

Molecular Weight

1041.20

Formula

C52H60N6O13S2

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

2-((1E,3E)-5-((E)-1-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium-5-sulfonate

InChI Key

RWTYSFWRLGGPLR-UHFFFAOYSA-N

SMILES

O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC(OCC(NCCCCNC(CCCCCN(C(C=CC(S(=O)(O)=O)=C4)=C4C/5(C)C)C5=C\C=C\C=C\C6=[N+](CC)C7=C(C=C(S(=O)([O-])=O)C=C7)C6(C)C)=O)=O)=C31)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.82 20

Preparing Stock Solutions for Thalidomide-Cyanine 5

The following data is based on the product molecular weight 1041.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 4.80 mL 24.01 mL 48.02 mL
1 mM 0.96 mL 4.80 mL 9.60 mL
2 mM 0.48 mL 2.40 mL 4.80 mL
10 mM 0.10 mL 0.48 mL 0.96 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 100 publications citing the usage of this product.

Product Documents for Thalidomide-Cyanine 5

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Thalidomide-Cyanine 5

For research use only

Citations for Thalidomide-Cyanine 5

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