Thalidomide

Key Product Details

Product Description

Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Anti-inflammatory; promotes T-cell activation. Predicted to reduce cytokine release in SARS-CoV-2 infection. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogenic and sedative-hypnotic. Promotes degradation of transcription factor SALL4.

Product Specifications for Thalidomide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Thalidomide

The following data is based on the product molecular weight 258.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

11 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	15.49 mL	77.45 mL	154.90 mL
1.25 mM	3.10 mL	15.49 mL	30.98 mL
2.5 mM	1.55 mL	7.75 mL	15.49 mL
12.5 mM	0.31 mL	1.55 mL	3.10 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 50 publications citing the usage of this product.

• Li Network bioinformatics analysis provides insight into drug repurposing for COVID-2019. Med.Drug Discov. 2021 PMID: 33817623
• Ito Identification of a primary target of Thal. teratogenicity. Science 2010 PMID: 20223979
• Donovan Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 2018 PMID: 30067223
• Sampaio Thal. selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J.Exp.Med. 1991 PMID: 1997652
• Zhang Thal. influences growth and vasculogenic mimicry channel formation in melanoma. J.Exp.Clin.Cancer Res. 2008 PMID: 18983651
• Makonkawkeyoon Thal. inhibits the replication of human-immunodeficiency-virus type 1. Proc.Natl.Acad.Sci.U.S.A. 1993 PMID: 8327469
• Kanbayashi Thal., a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport 1996 PMID: 8905685
• Boireau Thal. reduces MPTP-induced decrease in striatal DA levels in mice. Neurosci.Lett. 1997 PMID: 9364513

Product Documents for Thalidomide