Thioflavin X
Tocris Bioscience | Catalog # 8949
Key Product Details
Description
Wavelength
Product Description
Key information: Thioflavin X (ThX) is a next-generation cell-permeable fluorescent probe for the detection of amyloid aggregates. Displays 5-fold increase in brightness and 7-fold increase in binding affinity (Ki = 680 nM) compared to Thioflavin TUsed for: staining of Aβ oligomers, P301S Tau and α-Syn aggregates in brain tissues
Application: fluorescence microscopy and super resolution microscopy
Properties and Photophysical Data: Thioflavin X increases in fluorescence upon binding to α-Syn aggregates. Excitation and emission maxima (λ) in the presence of α-Syn aggregates are 421 nm and 490 nm, respectively; quantum yield = 0.81; extinction coefficient = 38,114 M-1cm-1
Optical Data
| λabs | 421 nm |
| λem | 490 nm |
| Extinction Coefficient (ε) | 38114 M-1cm-1 |
| Quantum Yield (φ) | 0.81 |
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Product Specifications for Thioflavin X
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.23 | 100 |
Preparing Stock Solutions for Thioflavin X
The following data is based on the product molecular weight 452.35.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.05 mL | 22.11 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Background References
References are publications that support the biological activity of the product.
- Needham ThX - a next-generation probe for the early detection of amyloid aggregates. Chem.Sci. 2020 PMID: 34122915
Product Documents for Thioflavin X
Certificate of Analysis
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Product Specific Notices for Thioflavin X
For research use only
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