Thiolutin

Tocris Bioscience | Catalog # 1567

Bacterial RNA polymerase inhibitor
Tocris Bioscience
Discontinued Product
1567 has been discontinued. View all Antibiotics products.

Key Product Details

Description

Bacterial RNA polymerase inhibitor
View all Antibiotics »

Product Description

Thiolutin is an antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.

Product Specifications for Thiolutin

Molecular Weight

228.28

Formula

C8H8N2O2S2

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide

CAS Number

87-11-6

PubChem ID

6870

InChI Key

MHMRAFONCSQAIA-UHFFFAOYSA-N

SMILES

O=C(N2C)C(NC(C)=O)=C1C2=CSS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5 22

Preparing Stock Solutions for Thiolutin

The following data is based on the product molecular weight 228.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.22 mM 19.91 mL 99.56 mL 199.12 mL
1.1 mM 3.98 mL 19.91 mL 39.82 mL
2.2 mM 1.99 mL 9.96 mL 19.91 mL
11 mM 0.40 mL 1.99 mL 3.98 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Thiolutin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Thiolutin

For research use only

Customer Reviews for Thiolutin (1)

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  • Study to figure out if Thiolutin suppresses tumor cell-induced angiogenesis
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/13/2019
    Used in study to figure out if Thiolutin suppresses tumor cell-induced angiogenesis.
    Thiolutin 1567

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