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Thiostrepton

Catalog #: 3267
3 Citations Datasheet / COA / SDS

Discontinued Product

3267 has been discontinued.
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Thiostrepton | CAS No. 1393-48-2 | Antibiotics
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Description: Antibiotic, inhibits protein synthesis

Purity: ≥90%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Thiostrepton is an antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.

Technical Data

M.Wt:
1664.89
Formula:
C72H85N19O18S5
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥90%
Storage:
Store at -20°C
CAS No:
1393-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Thiostrepton inhibition of tRNA delivery to the ribosome.
    Ruben et al.
    RNA, 2007;13:2091
  2. Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression.
    Kwok et al.
    Mol.Cancer Ther., 2008;7:2022
  3. Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.
    Rodnina et al.
    Proc.Natl.Acad.Sci.USA, 1999;96:9586

Product Datasheets

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Citations for Thiostrepton

The citations listed below are publications that use Tocris products. Selected citations for Thiostrepton include:

3 Citations: Showing 1 - 3

  1. FoxM1 Induced PTX Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter.
    Authors: Huang Et al.
    Mol Ther Oncolytics  2019;14:196
  2. Inhibition of FOXM1 by thiostrepton sensitizes medulloblastoma to the effects of chemotherapy.
    Authors: Lin Et al.
    Oncol Rep  2013;30:1739
  3. Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy.
    Authors: Uddin Et al.
    Am J Pathol  2011;178:537

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