Thiostrepton

Tocris Bioscience | Catalog # 3267

Antibiotic, inhibits protein synthesis
Tocris Bioscience
Discontinued Product
3267 has been discontinued. View all Antibiotics products.

Key Product Details

Description

Antibiotic, inhibits protein synthesis
View all Antibiotics »

Product Description

Thiostrepton is an antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.

Product Specifications for Thiostrepton

Molecular Weight

1664.89

Formula

C72H85N19O18S5

Storage

Store at -20°C

Purity

≥90% (HPLC)

CAS Number

1393-48-2

PubChem ID

16129666

InChI Key

NSFFHOGKXHRQEW-DVRIZHICSA-N

SMILES

C=C(C(NC(C(N)=O)=C)=O)NC(C1=CSC(C2=NC(C3=CSC(C(C(C)OC(C4=CC(C(C)O)=C(C=CC(NC(C(NC(C)C(NC(C(NC(C)C5=O)=O)=C)=O)=O)C(C)CC)C6O)C6=N4)=O)N7)=N3)C(CC2)(N5)C8=NC(C(NC(C(N/C(C9=NC(C(NC(C(O)(C)C(C)O)C%10=NC(C7=O)=CS%10)=O)CS9)=C/C)=O)C(O)C)=O)=CS8)=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.65 10

Preparing Stock Solutions for Thiostrepton

The following data is based on the product molecular weight 1664.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 6.01 mL 30.03 mL 60.06 mL
0.5 mM 1.20 mL 6.01 mL 12.01 mL
1 mM 0.60 mL 3.00 mL 6.01 mL
5 mM 0.12 mL 0.60 mL 1.20 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 39 publications citing the usage of this product.

Product Documents for Thiostrepton

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Thiostrepton

For research use only

Customer Reviews for Thiostrepton (1)

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  • Thiostrepton was used to treat acquired cisplatin resistance
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/27/2019
    Insoluble in the lower alcohols, nonpolar organic solvents, diluted aqueous acids or bases
    Thiostrepton was used to treat acquired cisplatin resistance in breast cancer cells under in in vitro conditions.
    Thiostrepton 3267

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