TL 0259

Key Product Details

Product Description

TL 0259 is a selective and highly potent Fgr and Lyn inhibitor (IC₅₀ values are 0.03 and 0.1 nM, respectively). Exhibits selectivity for Fgr and Lyn over other Src family kinases and other nonreceptor and receptor tyrosine kinases. Suppresses proliferation of acute myelogenous leukemia (AML) cell lines in vitro. Eliminates leukemic cells from spleen and bone of mice bearing AML xenografts. Orally bioavailable.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for TL 0259

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TL 0259

The following data is based on the product molecular weight 682.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.93 mL	14.65 mL	29.30 mL
2.5 mM	0.59 mL	2.93 mL	5.86 mL
5 mM	0.29 mL	1.47 mL	2.93 mL
25 mM	0.06 mL	0.29 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 87 publications citing the usage of this product.

• Weir Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo. ACS Chem.Biol. 2018 PMID: 29763550

Product Documents for TL 0259