Torcetrapib

Key Product Details

Product Description

Torcetrapib is an inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Torcetrapib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Torcetrapib

The following data is based on the product molecular weight 600.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.33 mL	16.65 mL	33.31 mL
2.5 mM	0.67 mL	3.33 mL	6.66 mL
5 mM	0.33 mL	1.67 mL	3.33 mL
25 mM	0.07 mL	0.33 mL	0.67 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Forrest Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increasing circulating levels of aldosterone. Br.J.Pharmacol. 2008 PMID: 18536749
• Connelly Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition. J.Cardiovascular Pharmacol. 2010 PMID: 20051879

Product Documents for Torcetrapib