tri-GalNAc biotin

Tocris Bioscience | Catalog # 7635

Biotinylated ASGPR ligand for LYTAC research and development
Tocris Bioscience

Key Product Details

Description

Biotinylated ASGPR ligand for LYTAC research and development
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Product Description

Tri-GalNAc-biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development, comprising a triantennary N-acetylgalactosamine (GalNAc) joined by a PEG linker to biotin. Tri-GalNAc-biotin can induce ASGPR-mediated endocytosis and trafficking of fluorescently labeled neutravidin for lysosomal degradation in HepG2 cells in a time-dependent manner. The increase in fluorescent signal within cells plateaus after 16-20h, and this effect can be inhibited by addition of tri-GalNAc COOH (Cat. No. 7401).

Product Specifications for tri-GalNAc biotin

Molecular Weight

1916.21

Formula

C83H146N14O34S

Storage

Store at -20°C

Purity

≥90% (HPLC)

InChI Key

GFCCTIAQGWLOHY-PTYDYDFOSA-N

SMILES

O[C@@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OCCCCC(NCCCNC(CCOCC(NC(CCNC(CCOCCOCCOCCNC(CCCC[C@@H]2SC[C@@](N3)([H])[C@]2([H])NC3=O)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@@H]5O[C@H](CO)[C@H](O)[C@H](O)[C@H]5NC(C)=O)=O)=O)=O)=O)O[C@@H]1CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 95.81 50

Preparing Stock Solutions for tri-GalNAc biotin

The following data is based on the product molecular weight 1916.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.04 mL 5.22 mL 10.44 mL
2.5 mM 0.21 mL 1.04 mL 2.09 mL
5 mM 0.10 mL 0.52 mL 1.04 mL
25 mM 0.02 mL 0.10 mL 0.21 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for tri-GalNAc biotin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for tri-GalNAc biotin

For research use only

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