Chemical Name: (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Biological ActivityTriptolide inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC50 = 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Triptolide blocks RNA synthesis in HeLa cells (IC50 = 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and induces apoptosis by blocking TNF-α-mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
XPB, a subunit of TFIIH, is a target of the natural product triptolide.
Titov et al.
Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional activation.
Qui et al.
PG490 (Triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cells.
Lee et al.
Citations for Triptolide
The citations listed below are publications that use Tocris products. Selected citations for Triptolide include:
7 Citations: Showing 1 - 7
Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing.
Authors: Shao Et al.
A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing.
Authors: Tettey Et al.
Cell Rep 2019;27:3770
BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication.
Authors: Bowry Et al.
Cell Rep 2018;25:2061
Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation.
Authors: Liao and Mizzen
Epigenetics Chromatin 2017;10:29
Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.
Authors: Zhao Et al.
Sci Rep 2015;5:7647
The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.
Authors: Filone Et al.
PLoS Pathog 2014;10:e1003904
Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1).
Authors: Vollmer Et al.
J Biol Chem 2012;287:35212
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