Trolox

Tocris Bioscience | Catalog # 6002

Antifade reagent; antioxidant vitamin E derivative; cell permeable and water soluble
Tocris Bioscience

Key Product Details

Description

Antifade reagent; antioxidant vitamin E derivative; cell permeable and water soluble
View all Additional Antioxidant Compounds »

Product Description

Trolox is an antioxidant vitamin E derivative; suppresses osteoclast formation and inhibits IL-1-induced osteoclast bone loss. Also inhibits ferroptosis. Commonly used antifade reagent in live cell imaging; suppresses blinking and photobleaching. Cell-permeable and water soluble.

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Product Specifications for Trolox

Molecular Weight

250.29

Formula

C14H18O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

CAS Number

53188-07-1

PubChem ID

40634

InChI Key

GLEVLJDDWXEYCO-UHFFFAOYSA-N

SMILES

CC1=C(C(C)=C2CCC(OC2=C1C)(C(O)=O)C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.03 100
Ethanol 25.03 100

Preparing Stock Solutions for Trolox

The following data is based on the product molecular weight 250.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.00 mL 19.98 mL 39.95 mL
5 mM 0.80 mL 4.00 mL 7.99 mL
10 mM 0.40 mL 2.00 mL 4.00 mL
50 mM 0.08 mL 0.40 mL 0.80 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 33 publications citing the usage of this product.

Product Documents for Trolox

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Trolox

For research use only

Customer Reviews for Trolox (1)

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  • Trolox
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Hepatocarcinoma HepG2
    Verified Customer | Posted 09/30/2025
    I investigated the effects of Trolox as an antioxidant on liver cancer cell HepG2 proliferation. Trolox appeared to increase the transcriptional levels of the master regulator of cellular redox balance Nrf2 and down-stream metabolic enzymes, which might underlie the positive effects of Trolox on cancer cell proliferation.
    Trolox 6002

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