U 104

Key Product Details

Product Description

U 104 is a potent carbonic anhydrase (CA) inhibitor (K_i values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.

Product Specifications for U 104

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for U 104

The following data is based on the product molecular weight 309.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.23 mL	16.16 mL	32.33 mL
5 mM	0.65 mL	3.23 mL	6.47 mL
10 mM	0.32 mL	1.62 mL	3.23 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lou Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 PMID: 21415165

Product Documents for U 104