UCB 9386

Key Product Details

Product Description

UCB 9386 is a potent and selective central nervous system penetrant NUAK1 (NUAK family SnF1-like kinase-1) inhibitor (pIC₅₀= 10.1). Kinome selectivity measured in the diversity panel shows that only Jak2 and Nuak2 are inhibited more than 50% at 10 nM. In vivo, UCB 9386 exhibits high brain penetrance.

Product Specifications for UCB 9386

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UCB 9386

The following data is based on the product molecular weight 478.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.45 mL	20.90 mL
5 mM	0.42 mL	2.09 mL	4.18 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Poullennec Discovery of UCB9386: a potent, selective, and brain-penetrant Nuak1 inhibitor suitable for in vivo pharmacological studies. J Med Chem 2024 PMID: 39588908

Product Documents for UCB 9386