UCPH 101

Key Product Details

Product Description

UCPH 101 is a selective non-substrate inhibitor of EAAT1 (IC₅₀ values are 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3 respectively). Also demonstrates no significant inhibition at EAAT4 or EAAT5 in a patch-clamp electrophysiology assay (at final concentration up to 10 μM).

Product Specifications for UCPH 101

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UCPH 101

The following data is based on the product molecular weight 422.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.47 mL	47.34 mL	94.68 mL
1.25 mM	1.89 mL	9.47 mL	18.94 mL
2.5 mM	0.95 mL	4.73 mL	9.47 mL
12.5 mM	0.19 mL	0.95 mL	1.89 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Abrahamsen Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J.Neurosci. 2013 PMID: 23325245
• Erichsen Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). J.Med.Chem. 2010 PMID: 20857912
• Bunch Excitatory amino acid transporters as potential drug targets. Exp.Opin.Ther.Targets
• Jensen Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1. J.Med.Chem. 2009 PMID: 19161278

Product Documents for UCPH 101