UFP-101

Name: UFP-101
Brand: Tocris Bioscience
SKU: 1552

Tocris Bioscience | Catalog # 1552

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Citations (19)

Product Documents

Potent, selective silent antagonist for NOP

Discontinued Product

1552 has been discontinued. View all NOP Receptor Antagonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent, selective silent antagonist for NOP

Alternative Names

[Nphe¹,Arg¹⁴,Lys¹⁵]Nociceptin-NH₂

View all NOP Receptor Antagonists »

Product Description

UFP-101 is a potent, selective and competitive silent antagonist for the NOP opioid receptor. Binds to NOP with high affinity (pK_i = 10.24) and displays > 3000-fold selectivity over δ, μ and κ opioid receptors. Antinociceptive and opposes the action of nociceptin in vivo.

Product Specifications for UFP-101

Molecular Weight

1908.19

Formula

C₈₂H₁₃₈N₃₂O₂₁

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

849024-68-6

PubChem ID

16152632

InChI Key

DOLKPWDXAQZKNJ-LGCGZHPXSA-N

SMILES

C[C@@H](O)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)CNCC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

McDonald UFP-101, a high affinity antagonist for the nociceptin/orphanin FQ receptor: radioligand and GTPγ³⁵ binding studies. Naunyn Schmiedebergs Arch.Pharmacol. 2003 PMID: 12595960
Gavioli Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test. Eur.J.Neurosci. 2003 PMID: 12752799
Marti Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex. Br.J.Pharmacol. 2003 PMID: 12522077
Calo [Nphe¹,Arg¹⁴,Lys¹⁵]Nociceptin-NH₂, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. Br.J.Pharmacol. 2002 PMID: 12010780

Product Documents for UFP-101

Certificate of Analysis

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Product Specific Notices for UFP-101

For research use only

Related Research Areas

Neurotransmitter G Protein-Coupled Receptors

Citations for UFP-101

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