UNC 2327

Key Product Details

Product Description

UNC 2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC₅₀ = 230 nM). Noncompetitive with both the peptide substrate and cofactor.

Product Specifications for UNC 2327

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UNC 2327

The following data is based on the product molecular weight 319.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.66 mL	31.31 mL
5 mM	0.63 mL	3.13 mL	6.26 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Liu Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 2013 PMID: 23445220

Product Documents for UNC 2327