V 9302 hydrochloride
Chemical Name: (2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid hydrochloride
Purity: ≥97%
Biological Activity
V 9302 hydrochloride is an alanine-serine-cysteine transporter 2 (ASCT2, encoded by gene SLC1A5) inhibitor. It inhibits glutamate uptake (IC50 = 9.6 μM in HEK-293 cells). It reduces cancer cell growth and proliferation, also increases cell death and oxidative stress in vitro and in vivo. V 9302 hydrochloride inhibits mTORC1 activity, mitochondrial respiration, proliferation and migration of vascular smooth muscle cells (VSMCs).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
Schulte ML, Fu A, Zhao P et al.
Nat. Med.
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