Valdecoxib

Key Product Details

Product Description

Valdecoxib is a selective and potent COX-2 inhibitor (in vitro IC₅₀ values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Valdecoxib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Valdecoxib

The following data is based on the product molecular weight 314.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.18 mL	15.91 mL	31.81 mL
5 mM	0.64 mL	3.18 mL	6.36 mL
10 mM	0.32 mL	1.59 mL	3.18 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Walker A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors. Biochem.J. 2001 PMID: 11463341
• Gierse Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J.Pharmacol.Exp.Ther. 2005 PMID: 15494548
• Talley 4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J.Med.Chem. 2000 PMID: 10715145

Product Documents for Valdecoxib