Valinomycin

Tocris Bioscience | Catalog # 3373

Selective K+ ionophore
Tocris Bioscience

Key Product Details

Description

Selective K+ ionophore
View all Ionophores »

Product Description

Valinomycin is a selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

Product Specifications for Valinomycin

Molecular Weight

1111.32

Formula

C54H90N6O18

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)

CAS Number

2001-95-8

PubChem ID

3000706

InChI Key

FCFNRCROJUBPLU-DNDCDFAISA-N

SMILES

O=C([C@H](C)OC([C@@H]([C@@H](C)C)NC([C@H](OC([C@@H](NC([C@@H](O1)C)=O)[C@@H](C)C)=O)[C@@H](C)C)=O)=O)N[C@@H]([C@@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@@H](C(O[C@@H](C)C(N[C@@H]([C@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@H]([C@H](C)C)C1=O)=O)=O)=O)=O)[C@H](C)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.78 25
Ethanol 27.78 25

Preparing Stock Solutions for Valinomycin

The following data is based on the product molecular weight 1111.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 3.60 mL 18.00 mL 35.99 mL
1.25 mM 0.72 mL 3.60 mL 7.20 mL
2.5 mM 0.36 mL 1.80 mL 3.60 mL
12.5 mM 0.07 mL 0.36 mL 0.72 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 24 publications citing the usage of this product.

Product Documents for Valinomycin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Valinomycin

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Valinomycin (2)

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  • The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound
    Name: Anonymous
    Species: C. albicans
    Assay Type: In Vitro
    Verified Customer | Posted 02/01/2020
    Biologically active compounds that have been documented to interact with a wide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat. # 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience
    Valinomycin 3373
  • Valimomycin was used in oxidative phosphorylation studies
    Name: Jade Smith
    Species: Human
    Verified Customer | Posted 02/05/2019
    Valimomycin was used in oxidative phosphorylation studies. Performed well and gives repeatable results.
    Valinomycin 3373

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