Chemical Name: N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate
Biological ActivityVatalanib succinate is a potent VEGFR inhibitor (IC50 values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs in vitro and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-β, c-Kit and c-Fms. Potent aromatase inhibitor (IC50 = 50 nM). Orally available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 inhibits aromatase.
Banerjee et al.
Cancer Res., 2009;69:4716
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.
Wood et al.
Cancer Res., 2000;60:2178
New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis.
Bold et al.
Citations for Vatalanib succinate
The citations listed below are publications that use Tocris products. Selected citations for Vatalanib succinate include:
2 Citations: Showing 1 - 2
Osteoblasts pattern endothelium and somatosensory axons during zebrafish caudal fin organogenesis.
Authors: Jeffrey P Et al.
Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization.
Authors: Rasmussen Et al.
Dev Cell 2018;46:344
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