Veratridine

Tocris Bioscience | Catalog # 2918

Voltage-gated Na+ channel opener
Tocris Bioscience

Key Product Details

Description

Voltage-gated Na+ channel opener
View all Additional Voltage-gated Sodium Channel Products »

Product Description

Veratridine is a voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.

Product Specifications for Veratridine

Molecular Weight

673.79

Formula

C36H51NO11

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol

CAS Number

71-62-5

PubChem ID

6280

InChI Key

FVECELJHCSPHKY-YFUMOZOISA-N

SMILES

O=C(C8=CC=C(OC)C(OC)=C8)O[C@H]1CC[C@@]2(C)[C@@]3([H])[C@@](O)1O[C@@]42[C@@]([C@@](C[C@H](O)[C@@]6(O)[C@]([H])5CN7[C@](CC[C@H](C)C7)([H])[C@@](O)6C)(O)[C@@]5(O)C4)([H])CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.69 50

Preparing Stock Solutions for Veratridine

The following data is based on the product molecular weight 673.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.97 mL 14.84 mL 29.68 mL
2.5 mM 0.59 mL 2.97 mL 5.94 mL
5 mM 0.30 mL 1.48 mL 2.97 mL
25 mM 0.06 mL 0.30 mL 0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 45 publications citing the usage of this product.

Product Documents for Veratridine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Veratridine

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Veratridine (2)

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  • Voltage sensitive sodium channel opening
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 11/19/2018
    Can be used to activate and open voltage sensitive sodium channels in neurons. Elicits rapid reaction when applied directly to tissue.
  • Increases intracellular Na+ and tissue swelling
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Verified Customer | Posted 05/02/2018
    Verstridine is a voltage-gated sodium channel agonist. It increases intracellular Na+ concentration and also induces cellular and tissue swelling. We used at 50 microM to rat brain slices.

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