Verteporfin

Tocris Bioscience | Catalog # 5305

YAP inhibitor
Tocris Bioscience

Key Product Details

Description

YAP inhibitor

Alternative Names

Visudyne
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Product Description

Verteporfin is a YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.

Product Specifications for Verteporfin

Molecular Weight

718.79

Formula

C41H42N4O8

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

CAS Number

129497-78-5

PubChem ID

5362420

InChI Key

YHNBVDZVUQFVLS-SKJZPIBWSA-N

SMILES

CC(C(/C=C1N/C([C@@]2(C)C\1=CC=C(C(OC)=O)[C@H]2C(OC)=O)=C\C3=N/C(C(CCC(O)=O)=C3C)=C\4)=N/5)=C(C=C)C5=C\C6=C(C)C(CCC(OC)=O)=C4N6.CC(C(/C=C7N/C([C@@]8(C)C\7=CC=C(C(OC)=O)[C@H]8C(OC)=O)=C\C9=N/C(C(CCC(OC)=O)=C9C)=C\%10)=N/%11)=C(C=C)C%11=C\C%12=C(C)C(CCC(O)=O)=C%10N%12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.38 20

Preparing Stock Solutions for Verteporfin

The following data is based on the product molecular weight 718.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6.96 mL 34.78 mL 69.56 mL
1 mM 1.39 mL 6.96 mL 13.91 mL
2 mM 0.70 mL 3.48 mL 6.96 mL
10 mM 0.14 mL 0.70 mL 1.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 57 publications citing the usage of this product.

Product Documents for Verteporfin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Verteporfin

For research use only

Customer Reviews for Verteporfin (2)

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  • Generation of EPS-blastoids
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: EPS
    Verified Customer | Posted 02/27/2020
    2uM
    Verteporfin 5305
  • In vitro cell treatment using Verteporfin
    Name: Sara Piccirillo
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: cancer cell lines
    Verified Customer | Posted 01/16/2018
    Used it in in vitro treatment assays at concentration of 1 to 10microM for 72 hours. The treatment resulted in a significant time- and dose-dependent inhibition of cell growth & viability.

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