Vismodegib

Key Product Details

Product Description

Vismodegib is a potent hedgehog pathway inhibitor (IC₅₀ = 3 nM). It causes tumor regressions in allograft medulloblastoma mice model and tumor growth inhibition in a xenograft mouse models of colorectal cancer. Vismodegib is orally bioavailable.

Product Specifications for Vismodegib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Vismodegib

The following data is based on the product molecular weight 421.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.87 mL	23.74 mL
5 mM	0.47 mL	2.37 mL	4.75 mL
10 mM	0.24 mL	1.19 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Wong Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor. Xenobiotica 2009 PMID: 19845436
• Wong Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin.Cancer Res. 2011 PMID: 21610148
• Robarge GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg.Med.Chem.Lett. 2009 PMID: 19716296

Product Documents for Vismodegib