VPC 23019

Key Product Details

Product Description

VPC 23019 is a sphingosine-1-phosphate receptor antagonist; inhibits S1P₁ and S1P₃ receptors (pK_i values are 7.86 and 5.93 respectively).

Product Specifications for VPC 23019

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VPC 23019

The following data is based on the product molecular weight 372.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.37 mL	26.85 mL	53.71 mL
2.5 mM	1.07 mL	5.37 mL	10.74 mL
5 mM	0.54 mL	2.69 mL	5.37 mL
25 mM	0.11 mL	0.54 mL	1.07 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

• Aoki The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α₅β₁ and α_Vβ₃. J.Thromb.Haemost. 2007 PMID: 17403093
• Mihovilovic High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J.Lipid Res. 2007 PMID: 17264352
• Davis Sphingosine-1-phosphate analogs as receptor antagonists. J.Biol.Chem. 2005 PMID: 15590668

Product Documents for VPC 23019