VU 0071063

Key Product Details

Product Description

VU 0071063 is a selective activator of SUR1 K_ir6.2 channels and pancreatic β-cell K_ATP channels (EC₅₀ = 7 μM and 0.3-10.3 μM, respectively). VU 0071063 inhibits insulin secretion in pancreatic β-cells by inducing hyperpolarization of β-cell membranes and reduces voltage-dependent calcium channel activation and Ca²⁺ influx. VU 0071063 is active in vivo and brain penetrant.

Product Specifications for VU 0071063

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0071063

The following data is based on the product molecular weight 326.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	61.27 mL	306.37 mL	612.75 mL
0.25 mM	12.25 mL	61.27 mL	122.55 mL
0.5 mM	6.13 mL	30.64 mL	61.27 mL
2.5 mM	1.23 mL	6.13 mL	12.25 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kharade Structure-activity relationships, pharmacokinetics, and pharmacodynamics of the Kir6.2/SUR1-specific channel opener VU0071063. J.Pharmacol.Exp.Ther. 2019 PMID: 31201216
• Raphemot Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol.Pharmacol. 2014 PMID: 24646456

Product Documents for VU 0071063