VU 0155041

Key Product Details

Product Description

VU 0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu₄ receptors (EC₅₀ = 798 and 693 nM at human and rat mGlu₄ receptors respectively). Active in in vivo models of Parkinson's disease following i.c.v. administration. Also available as sodium salt (Cat. No. 3311).

Product Specifications for VU 0155041

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0155041

The following data is based on the product molecular weight 316.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.16 mL	15.81 mL	31.63 mL
5 mM	0.63 mL	3.16 mL	6.33 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Niswender Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol.Pharmacol. 2008 PMID: 18664603

Product Documents for VU 0155041