VU 0409551

Key Product Details

Product Description

VU 0409551 is a selective mGlu₅ positive allosteric modulator (EC₅₀ = 260 nM). Selective for mGlu₅ over other mGluR subtypes, as well as 66 other receptors and ion channels. Selectively potentiates mGlu₅ signaling via G_αq. Exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models. Brain penetrant and orally available.

Product Specifications for VU 0409551

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0409551

The following data is based on the product molecular weight 352.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Conde-Ceide Discovery of VU0409551/JNJ-46778212: An mGlu₅ positive allosteric modulator clinical candidate targeting schizophrenia. ACS Med.Chem.Lett. 2015 PMID: 26157544
• Ghoshal Role of mGlu5 receptors and inhibitory neurotransmission in M1 dependent muscarinic LTD in the prefrontal cortex: implications in Schizophrenia. ACS Chem.Neurosci. 2017 PMID: 28679049
• Rook Biased mGlu₅-positive allosteric modulators provide in vivo efficacy without potentiating mGlu₅ modulation of NMDAR currents. Neuron 2015 PMID: 25937172

Product Documents for VU 0409551