VU 0422288

Key Product Details

Product Description

VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC₅₀ values are 108, 125 and 146 nM for mGlu₄, mGlu₈ and mGlu₇ respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu₇-mediated reductions in excitatory post synaptic potentials in hippocampal slices.

Product Specifications for VU 0422288

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0422288

The following data is based on the product molecular weight 360.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.78 mL	13.88 mL	27.76 mL
5 mM	0.56 mL	2.78 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.78 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jalan-Sakrikar Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem.Neurosci. 2014 PMID: 25225882

Product Documents for VU 0422288