VU 0542270

Key Product Details

Product Description

VU 0542270 is a selective inhibitor of K_ir6.1/SUR2B K_ATP channels (IC₅₀ = 104 nM). Shows no activity at other K_ir channel types at up to 30 μM. Dose-dependently induces constriction of ductus arteriosus vessels.

Product Specifications for VU 0542270

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0542270

The following data is based on the product molecular weight 335.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.90 mL	29.81 mL
5 mM	0.60 mL	2.98 mL	5.96 mL
10 mM	0.30 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Li Discovery and characterization of VU0542270, the first selective inhibitor of vascular Kir6.1/SUR2B K_ATP channels. Mol.Pharmacol. 2024 PMID: 38302135

Product Documents for VU 0542270