VU 29

Key Product Details

Product Description

VU 29 is a potent allosteric potentiator at the rat mGlu₅ receptor (EC₅₀ = 9 nM); binds to the MPEP (Cat. No. 1212) allosteric site (K_{i app} = 244 nM). Selective for mGlu5 over mGlu₁ and mGlu₂ receptors (EC₅₀ values are 557 nM and 1.51 μM for mGlu₁ and mGlu₂ respectively). Potentiates both DHPG-induced LTP and threshold θ-burst stimulation (TBS)-induced LTP in rat hippocampal slices. Analog of CDPPB (Cat. No. 3235).

Product Specifications for VU 29

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 29

The following data is based on the product molecular weight 384.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.60 mL	13.01 mL	26.02 mL
5 mM	0.52 mL	2.60 mL	5.20 mL
10 mM	0.26 mL	1.30 mL	2.60 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• de Paulis Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J.Med.Chem. 2006 PMID: 16722652
• Ayala mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning. Neuropsychopharmacology 2009 PMID: 19295507
• Chen Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol.Pharmacol. 2007 PMID: 17303702

Product Documents for VU 29